Firstly, let's talk about the cooling aspect. Dermicool Prickly Heat Powder is known for its Instant cooling effect. It's cooling properties are derived from Menthol and Camphor, which provide immediate relief from the heat and itch. On the other hand, Medicated powders like Calamine contain Zinc Oxide, which acts as an astringent and dries up the moisture that causes prickly heat. Sulphur is another common ingredient which fights bacteria.